A system failure probability analysis method of cohesive slope considering the spatial variability of undrained shear strength is proposed.In this method, the local averaging parameter of the random field of undrained shear strength on slip surface is introduced as an equivalent parameter.The statistical characters of the equivalent parameter and t
Effect of repeat bolus dose of propofol on succinylcholine-induced fasciculations and myalgia
Background: Succinylcholine-induced fasciculations and myalgia are common and troublesome for the patients.A few studies have used propofol to minimize succinylcholine-induced fasciculations and myalgia, but none of these have used a repeat bolus dose.Materials and Methods: A prospective, randomized, double blind study was designed to assess the ef
HIV-infected cells are frequently clonally expanded after prolonged antiretroviral therapy: implications for HIV persistence
HIV infection TURMERIC is controlled but not eradicated by combination antiretroviral therapy (cART), and persistence during therapy represents a substantial barrier to strategies to eradicate infection.The nature of persistence is uncertain, and a number of mechanisms have been proposed to explain HIV persistence in vivo, including low-level HIV r
ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia
Background: The t(12;21)(p13;q22), which fuses ETV6 and RUNX1 Tumblers genes, is the most common genetic abnormality in children with B-cell precursor acute lymphoblastic leukaemia.The implication of the fusion protein in leukemogenesis seems to be clear.However, its role in the maintenance of the disease continues to be controversial.Methods: Gene